One reaction: can I play?
Me too? Seriously, I think this is a great set-up, and I wish I'd thought of it. I don't think there should be any reason why you couldn't say all that up front, maybe changing the last paragraph about the Harm Reduction zones being world-wide to something sweet and simple like "This is one of those places. We call it Sanctuary. [beat, beat] Ok, who wants which splat?"
I did a similar thing with the Windmills game I'm running now - Hey guys, it's mountain-top removal in the Appalachians. Who wants which? - and it worked great.